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HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells

27 Jan 2017

Abstract excerpt

Abstract Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid peroxidation, although detailed molecular regulators are largely unknown. Here, we show that heatshock 70-kDa protein 5 (HSPA5) negatively regulates ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cells. Mechanistically, activating transcription factor 4 (ATF4) resulted in the induction of HSPA5, which...

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PMID: 28130223
DOI: 10.1158/0008-5472.can-16-1979

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