Article

Exploring multi-omics latent embedding spaces for characterizing tumor heterogeneity and tumoral fitness effects

2023-07-07

Abstract excerpt

The ecological and evolutionary perspectives of tumorigenesis can be characterized as a process of microevolution in tumor cells that altered the tumor microenvironment and further induced tumor cell proliferation, metastasis, and the death of tumor patients. Here, we introduced XgeneVAE, an interpretable unsupervised deep learning framework that quantified the semantic changes in multi-omics embedding space for c...

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Literature Corpus work: 83b0558f-e7e4-5e48-acea-3d3c9fe61418
DOI: 10.1101/2023.07.05.547886

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