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Article

Early elevations of RAS protein level and activity are critical for the development of PDAC in the context of inflammation.

Cancer letters - 1 Apr 2024

Ma Jianjia, Gong Fanghua, Kim Eunice, Du James Xianxing, Leung Cindy, Song Qingchun, Logsdon Craig D, Luo Yongde, Li Xiaokun, Lu Weiqin

Abstract excerpt

The KRASG12D mutation was believed to be locked in a GTP-bound form, rendering it fully active. However, recent studies have indicated that the presence of mutant KRAS alone is insufficient; it requires additional activation through inflammatory stimuli to effectively drive the development of pancreatic ductal adenocarcinoma (PDAC). It remains unclear to what extent RAS activation occurs during the development of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38307409
DOI: 10.1016/j.canlet.2024.216694
PMCID: PMC11032208

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