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Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer

1 Feb 2024

Abstract excerpt

Microbes are an integral component of the tumor microenvironment. However, determinants of microbial presence remain ill-defined. Here, using spatial-profiling technologies, we show that bacterial and immune cell heterogeneity are spatially coupled. Mouse models of pancreatic cancer recapitulate the immune-microbial spatial coupling seen in humans. Distinct intra-tumoral niches are defined by T cells, with T...

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PMID: 38307029
DOI: 10.1016/j.xcrm.2024.101397

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