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Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

16 Nov 2022

Abstract excerpt

Abstract The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer types 1,2 . Intratumoral host–microbiota studies have so far largely relied on bulk tissue analysis 1–3 , which obscures the spatial distribution and localized effect of the microbiota within tumours. Here, by applying in situ spatial-profiling technologies 4 and single-cell RNA sequencing 5 to...

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PMID: 36385528
DOI: 10.1038/s41586-022-05435-0

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