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Article

Dysregulation of the circRNA_0087207/miR-548c-3p/PLSR1-TGFB2 axis in Leber hereditary optic neuropathy in vitro.

Journal of the Chinese Medical Association : JCMA - 1 Mar 2024

Yang Yi-Ping, Chang Yuh-Lih, Chiou Guang-Yuh, Lee Meng-Shiue, Wu You-Ren, Chen Po-Wei, Lin Yi-Ying, Lai Wei-Yi, Liu Yu-Hao, Hwang De-Kuang, Chien Yueh

Abstract excerpt

BACKGROUND: Leber hereditary optic neuropathy (LHON) is mainly the degeneration of retinal ganglion cells (RGCs) associated with high apoptosis and reactive oxygen species (ROS) levels, which is accepted to be caused by the mutations in the subunits of complex I of the mitochondrial electron transport chain. The treatment is still infant while efforts of correcting genes or using antioxidants do not bring good...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38305450
DOI: 10.1097/JCMA.0000000000001063
PMCID: PMC12718843

Genes

TGFB2
PLSCR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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