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Article

Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays.

SLAS discovery : advancing life sciences R & D - 1 Apr 2024

Inniss Nicole L, Rzhetskaya Margarita, Ling-Hu Ted, Lorenzo-Redondo Ramon, Bachta Kelly E, Satchell Karla J F, Hultquist Judd F

Abstract excerpt

SARS-CoV-2 nsp13 helicase is an essential enzyme for viral replication and a promising target for antiviral drug development. This study compares the double-stranded RNA (dsRNA) unwinding activity of nsp13 and the Omicron nsp13R392C variant, which is predominant in currently circulating lineages. Using in vitro gel- and fluorescence-based assays, we found that both nsp13 and nsp13R392C have dsRNA unwinding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38301954
DOI: 10.1016/j.slasd.2024.01.006
PMCID: PMC11160173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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