Article
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region.
Nature communications - 31 Jan 2024
Ishikawa Yuki, Tanaka Nao, Asano Yoshihide, Kodera Masanari, Shirai Yuichiro, Akahoshi Mitsuteru, Hasegawa Minoru, Matsushita Takashi, Saito Kazuyoshi, Motegi Sei-Ichiro, Yoshifuji Hajime, Yoshizaki Ayumi, Kohmoto Tomohiro, Takagi Kae, Oka Akira, Kanda Miho, Tanaka Yoshihito, Ito Yumi, Nakano Kazuhisa, Kasamatsu Hiroshi, Utsunomiya Akira, Sekiguchi Akiko, Niiro Hiroaki, Jinnin Masatoshi, Makino Katsunari, Makino Takamitsu, Ihn Hironobu, Yamamoto Motohisa, Suzuki Chisako, Takahashi Hiroki, Nishida Emi, Morita Akimichi, Yamamoto Toshiyuki, Fujimoto Manabu, Kondo Yuya, Goto Daisuke, Sumida Takayuki, Ayuzawa Naho, Yanagida Hidetoshi, Horita Tetsuya, Atsumi Tatsuya, Endo Hirahito, Shima Yoshihito, Kumanogoh Atsushi, Hirata Jun, Otomo Nao, Suetsugu Hiroyuki, Koike Yoshinao, Tomizuka Kohei, Yoshino Soichiro, Liu Xiaoxi, Ito Shuji, Hikino Keiko, Suzuki Akari, Momozawa Yukihide, Ikegawa Shiro, Tanaka Yoshiya, Ishikawa Osamu, Takehara Kazuhiko, Torii Takeshi, Sato Shinichi, Okada Yukinori, Mimori Tsuneyo, Matsuda Fumihiko, Matsuda Koichi, Amariuta Tiffany, Imoto Issei, Matsuo Keitaro, Kuwana Masataka, Kawaguchi Yasushi, Ohmura Koichiro, Terao Chikashi
Abstract excerpt
Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region, which shows a penetrating association in the Asian population, while a complete linkage disequilibrium SNP, rs10917688, is found in a cis-regulatory element for IRF8. IRF8 is...
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