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Iatrogenic Alzheimer’s disease in recipients of cadaveric pituitary-derived growth hormone

29 Jan 2024

Abstract excerpt

Alzheimer's disease (AD) is characterized pathologically by amyloid-beta (Aβ) deposition in brain parenchyma and blood vessels (as cerebral amyloid angiopathy (CAA)) and by neurofibrillary tangles of hyperphosphorylated tau. Compelling genetic and biomarker evidence supports Aβ as the root cause of AD. We previously reported human transmission of Aβ pathology and CAA in relatively young adults who had died of...

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PMID: 38287166
DOI: 10.1038/s41591-023-02729-2

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