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Article

Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years.

Brain : a journal of neurology - 1 Nov 2015

Rudge Peter, Jaunmuktane Zane, Adlard Peter, Bjurstrom Nina, Caine Diana, Lowe Jessica, Norsworthy Penny, Hummerich Holger, Druyeh Ron, Wadsworth Jonathan D F, Brandner Sebastian, Hyare Harpreet, Mead Simon, Collinge John

Abstract excerpt

Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadaver-sourced growth hormone during childhood are still being seen in the UK 30 years after cessation of this treatment. Of the 77 patients who have developed iatrogenic Creutzfeldt-Jakob disease, 56 have been genotyped. There has been a marked change in genotype profile at polymorphic codon 129 of the prion protein gene (PRNP) from...

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Source

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Identifiers

PMID: 26268531
DOI: 10.1093/brain/awv235
PMCID: PMC4620512

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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