Article
UK Iatrogenic Creutzfeldt-Jakob disease: investigating human prion transmission across genotypic barriers using human tissue-based and molecular approaches.
Acta neuropathologica - 1 Apr 2017
Ritchie Diane L, Barria Marcelo A, Peden Alexander H, Yull Helen M, Kirkpatrick James, Adlard Peter, Ironside James W, Head Mark W
Abstract excerpt
Creutzfeldt-Jakob disease (CJD) is the prototypic human prion disease that occurs most commonly in sporadic and genetic forms, but it is also transmissible and can be acquired through medical procedures, resulting in iatrogenic CJD (iCJD). The largest numbers of iCJD cases that have occurred worldwide have resulted from contaminated cadaveric pituitary-derived human growth hormone (hGH) and its use to treat...
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