Article
Iatrogenic Creutzfeldt-Jakob disease: an example of the interplay between ancient genes and modern medicine.
Neurology - 1 Feb 1994
Brown P, Cervenáková L, Goldfarb L G, McCombie W R, Rubenstein R, Will R G, Pocchiari M, Martinez-Lage J F, Scalici C, Masullo C
Abstract excerpt
We tested DNA from 15 centrally infected cases of iatrogenic Creutzfeldt-Jakob disease (CJD) (dura mater or corneal homografts and stereotactic EEG electrodes), 11 peripherally infected cases (native human growth hormone or gonadotrophin), and 110 control individuals for the presence of mutations in the chromosome 20 amyloid gene. No patient or control had any of the known pathogenic point or insert mutations...
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