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Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Display Altered Proteomes at Early Stages of Differentiation

15 Dec 2021

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder characterized by loss of motor neurons (MN) in the spinal cord leading to progressive muscle atrophy and weakness. SMA is caused by mutations in the survival motor neuron 1 ( SMN1 ) gene, resulting in reduced levels of survival motor neuron (SMN) protein. The mechanisms that link...

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PMID: 34984269
DOI: 10.1021/acsomega.1c04688

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