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Article

Biallelic hexose-6-phosphate dehydrogenase variants cause mitochondrial dysfunction underlying Parkinson's disease.

Science bulletin - 15 Aug 2026

Zhao Miao, Zhao Yuwen, Huang Juan, Guo Yu, Yu Wenjun, Hou Haiyan, Huang Yilin, Du Xinying, Zhang Yu, Xie Mujun, Ren Zuowen, Guan Haoyu, Pan Hongxu, Xu Wenwen, Sun Qiying, Xu Qian, Lv Lingling, Wang Chunyu, Lei Lifang, Wu Heng, Shen Lu, Jiang Hong, Yan Xinxiang, Li Jinchen, Zheng Pengli, Guo Jifeng, Tang Beisha, Tan Jieqiong, Liu Zhenhua

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disorder influenced by complex genetic and environmental factors. We report that biallelic variants in hexose-6-phosphate dehydrogenase (H6PD), which encodes a key enzyme in the endoplasmic reticulum (ER) pentose phosphate pathway, contribute to PD and investigate its role in maintaining mitochondrial homeostasis. Through whole-exome sequencing of 2223...

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Alleles
Endoplasmic Reticulum
PINK1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

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Identifiers

PMID: 42463407
DOI: 10.1016/j.scib.2026.07.038

Genes

H6PD
PINK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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