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Article

Mutated JAK2 signal transduction in human induced pluripotent stem cell (iPSC)-derived megakaryocytes.

Platelets - 4 Jul 2022

Pawinwongchai Jaturawat, Jangprasert Panchalee, Nilsri Nungruthai, Israsena Nipan, Rojnuckarin Ponlapat

Abstract excerpt

Janus kinase 2 (JAK2) gene mutations are the main drivers for polycythemia vera (PV) and essential thrombocythemia (ET). The mechanisms of single altered gene causing two different diseases are unclear. Additionally, novel treatments specifically targeting mutated JAK2 proteins are needed. In this study, the induced pluripotent stem cells (iPSCs) were virally transduced to express wild-type JAK2 (JAK2WT),...

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PMID: 34749590
DOI: 10.1080/09537104.2021.1981850

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