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A shadow in the treatment of acute leukemia: lineage switch

20 Mar 2025

Abstract excerpt

Lineage switch is a rare phenomenon in which acute myeloid leukemia (AML) transforms into acute lymphoblastic leukemia (ALL) and vice versa, sharing the same clonal origin. It is more common for AML to relapse as ALL. Cytogenetics, microenvironment, and preceding therapies are associated with lineage switch. Since the etiology of lineage switch is unclear, presumptions include clonal selection, pluripotent stem...

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PMID: 40123764
DOI: 10.1097/bs9.0000000000000220

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