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Lineage switch in childhood acute leukemia: An unusual event with poor outcome

21 May 2012

Abstract excerpt

Although rarely, switches between lymphoid and myeloid lineages may occur during treatment of acute leukemias (AL). Correct diagnosis relies upon confirmation by immunophenotyping of the lineage conversion and certification that the same cytogenetic/molecular alterations remain despite the phenotypic changes. From a total of 1,482 AL pediatric patients, we report nine cases of lineage conversion (0.6%), seven...

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PMID: 22685031
DOI: 10.1002/ajh.23266

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