Article
Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle.
Microbes and infection - 1 Oct 2014
Pálmai-Pallag Timea, Bachrati Csanád Z
Abstract excerpt
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and host cell-derived damage associated molecular patterns (DAMPs) by the pattern recognition receptors (PRRs). DNA as a molecular PAMP or DAMP is sensed directly or...
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