Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NRF2 mutation enhances the immune escape of hepatocellular carcinoma by reducing STING activation.

Biochemical and biophysical research communications - 26 Feb 2024

Li Cheng, Liang Gang, Yan Ke, Wang Yongheng

Abstract excerpt

The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor usually hyperactivated in hepatocellular carcinoma (HCC). In addition, about 14 % of HCC patients carry mutation in NRF2 or Kelch-like ECH-associated protein 1 (Keap1), a NRF2 inhibitor, both of which lead to constitutive activation of NRF2. It has been widely reported that NRF2 plays important roles in the proliferation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Kelch-Like ECH-Associated Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms

Share to Membrane Proteins

Share to Mutation

Share to NF-E2-Related Factor 2

Share to Signal Transduction

Share to Tumor Escape

Source

Identifiers

PMID: 38271834
DOI: 10.1016/j.bbrc.2024.149536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NRF2 mutation enhances the immune escape of hepatocellular carcinoma by reducing STING activation.PMID 38271834Read ↗

Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer.Semantic proximity Read ↗

Nrf2: bane or blessing in cancer?Semantic proximity Read ↗

NRF2 Participates in the Suppressive Tumor Immune Microenvironment of KRAS/KEAP1 Co-Mutant Non-Small Cell Lung Cancer by Inhibiting the STING PathwaySemantic proximity Read ↗

The Dual Roles of NRF2 in Cancer.Semantic proximity Read ↗

Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis.Semantic proximity Read ↗

KEAP1/NRF2 (NFE2L2) mutations in NSCLC - Fuel for a superresistant phenotype?Semantic proximity Read ↗

NRF2 DLG Domain Mutations Identified in Japanese Liver Cancer Patients Affect the Transcriptional Activity in HCC Cell Lines.Semantic proximity Read ↗

Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance.Semantic proximity Read ↗

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of TumourigenesisSemantic proximity Read ↗

NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer.Semantic proximity Read ↗

New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.Semantic proximity Read ↗

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.