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Human papillomavirus E7 protein induces homologous recombination defects and PARPi sensitivity

1 Jan 2024

Abstract excerpt

PURPOSE: Cervical cancer is a common gynecological malignancy, pathologically associated with persistent infection of high-risk types of human papillomavirus (HPV). Previous studies revealed that HPV-positive cervical cancer displays genomic instability; however, the underlying mechanism is not fully understood. METHODS: To investigate if DNA damage responses are aggravated in precancerous lesions of HPV-positive...

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PMID: 38263342
DOI: 10.1007/s00432-023-05511-6

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