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Genomic Signatures in HPV-Associated Tumors

5 Oct 2021

Abstract excerpt

Papillomaviruses dysregulate the G1/S cell cycle transition in order to promote DNA synthesis in S phase, which is a requirement for viral replication. The human papillomaviruses (HPV) E6 and E7 oncoproteins mediate degradation of the cell cycle regulators p53 and Rb, which are two of the most universally disrupted tumor-suppressor genes in all of cancer. The G1/S checkpoint is activated in normal cells to allow...

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PMID: 34696429
DOI: 10.3390/v13101998

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