Article
A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS.
Autophagy - 1 Jun 2024
Iskandar Kartini, Foo Jonathan, Liew Angeline Qiu Xia, Zhu Haiyuxin, Raman Deepika, Hirpara Jayshree L, Leong Yan Yi, Babak Maria V, Kirsanova Anna A, Armand Anne-Sophie, Oury Franck, Bellot Gregory, Pervaiz Shazib
Abstract excerpt
RAS is one of the most commonly mutated oncogenes associated with multiple cancer hallmarks. Notably, RAS activation induces intracellular reactive oxygen species (ROS) generation, which we previously demonstrated as a trigger for autophagy-associated execution of mutant KRAS-expressing cancer cells. Here we report that drug (merodantoin; C1)-induced activation of mutant KRAS promotes phospho-AKT S473-dependent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.