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Article

Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2.

Journal of experimental & clinical cancer research : CR - 14 Dec 2023

Kim Dasom, Min Dongwha, Kim Joohee, Kim Min Jung, Seo Yerim, Jung Byung Hwa, Kwon Seung-Hae, Ro Hyunju, Lee Seoee, Sa Jason K, Lee Ji-Yun

Abstract excerpt

BACKGROUND: Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine, and fatty acid absorption and glycolysis. Lately, sotorasib was approved by the FDA as a first-in-class KRAS-G12C inhibitor. However, sotorasib still has a derivative barrier, which is not...

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Identifiers

PMID: 38093368
DOI: 10.1186/s13046-023-02922-8
PMCID: PMC10720203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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