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Article

Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2024

Guan Shaoxing, Chen Xi, Wei Yuru, Wang Fei, Xie Wen, Chen Youhao, Liang Heng, Zhu Xia, Yang Yunpeng, Fang Wenfeng, Huang Yan, Zhao Hongyun, Zhang Xiaoxu, Liu Shu, Zhuang Wei, Huang Min, Wang Xueding, Zhang Li

Abstract excerpt

PURPOSE: Although somatic mutations were explored in depth, limited biomarkers were found to predict the resistance of EGFR tyrosine kinase inhibitors (EGFR-TKI). Previous studies reported N6-methyladenosine (m6A) levels regulated response of EGFR-TKIs; whether the germline variants located in m6A sites affected resistance of EGFR-TKIs is still unknown. EXPERIMENTAL DESIGN: Patients with non-small cell lung...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38261467
DOI: 10.1158/1078-0432.CCR-23-2357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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