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USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer

7 Jun 2013

Abstract excerpt

PURPOSE: Common treatment modalities for non-small cell lung cancer (NSCLC) involve the EGF receptor-tyrosine kinase inhibitors (EGFR-TKIs) like gefitinib and erlotinib. However, the vast majority of treated patients acquire resistance to EGFR-TKIs, due, in large part, to secondary mutations in EGFR or amplification of the MET gene. Our purpose was to test ubiquitin-specific peptidase 8 (USP8) as a potential...

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PMID: 23748694
DOI: 10.1158/1078-0432.ccr-12-3696

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