Article

TRMT1-Mediated tRNA m22G Modification Drives Osimertinib Resistance via the ATXN3/USP25 Axis in Lung Adenocarcinoma

2026-02-11

Abstract excerpt

<title>Abstract</title> <p>Acquired resistance to Osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), remains a critical challenge in lung adenocarcinoma. Here, we identify ATXN3, a deubiquitinating enzyme, as a driver of Osimertinib resistance and a predictor of poor patient survival. Osimertinib treatment dynamically upregulates ATXN3 transcription, which stabilizes USP25 through deubiquitinat...

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Literature Corpus work: 271e2e2d-0430-5f52-b3d5-6662bbff5a89
DOI: 10.21203/rs.3.rs-8455091/v1

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