Article
Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy.
Oncogene - 14 Jul 2016
Wang Y-C, Wang S-A, Chen P-H, Hsu T-I, Yang W-B, Chuang Y-P, Su W-C, Liaw H-J, Chang W-C, Hung J-J
Abstract excerpt
Ubiquitin is a critical modifier regulating the degradation and function of its target proteins during posttranslational modification. Here we found that ubiquitin-specific peptidase 24 (USP24) is highly expressed in cell lines with enhanced malignancy and in late-stage lung cancer clinical samples. Studying single-nucleotide polymorphisms (SNPs) of USP24 using genomic DNA of lung cancer patients revealed an...
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