Article

Expression and Activation of the NF-κB Pathway Correlates with Methotrexate Resistance and Cell Proliferation in Acute Lymphoblastic Leukemia

2023-08-19

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Although prognosis continually improved along years, a significant proportion of patients still relapse from the disease due to leukemia resistance to therapy. Methotrexate (MTX), a folic acid antagonist, is a chemotherapy agent commonly used against ALL and a immune-system suppressant for rheumatoid arthritis, that presents multiple and compl...

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Literature Corpus work: 64629c04-a1b7-5d90-8be9-175060cd1ab6
DOI: 10.20944/preprints202308.1402.v1

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