Article
PNPLA3 Genotype and Dietary Fat Modify Concentrations of Plasma and Fecal Short Chain Fatty Acids and Plasma Branched-Chain Amino Acids.
Nutrients - 16 Jan 2024
Tauriainen Milla-Maria, Csader Susanne, Lankinen Maria, Lo Kwun Kwan, Chen Congjia, Lahtinen Olli, El-Nezamy Hani, Laakso Markku, Schwab Ursula
Abstract excerpt
The GG genotype of the Patatin-like phosphatase domain-containing 3 (PNPLA3), dietary fat, short-chain fatty acids (SCFA) and branched-chain amino acids (BCAA) are linked with non-alcoholic fatty liver disease. We studied the impact of the quality of dietary fat on plasma (p) and fecal (f) SCFA and p-BCAA in men homozygous for the PNPLA3 rs738409 variant (I148M). Eighty-eight randomly assigned men (age 67.8 ± 4.3...
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