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Article

PNPLA3 I148M variant links to adverse metabolic traits in MASLD during fasting and feeding

10 May 2025

Abstract excerpt

Background & Aims The PNPLA3 rs738409 polymorphism is the most abundant genetic risk factor associated with progression of metabolic dysfunction-associated steatotic liver disease (MASLD) to steatohepatitis (MASH) and fibrosis. While fasting and feeding affect PNPLA3 expression, molecular insights on the pathophysiological influence remain scarce. Methods We analyzed 353 serum samples of MASLD patients from two...

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PMID: 40677694
DOI: 10.1016/j.jhepr.2025.101450

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