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Article

Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.

The Journal of clinical endocrinology and metabolism - 17 Jun 2024

Condello Vincenzo, Poma Anello M, Macerola Elisabetta, Vignali Paola, Paulsson Johan O, Zedenius Jan, Basolo Fulvio, Juhlin C Christofer

Abstract excerpt

BACKGROUND: Mutations in micro-RNA (miRNA) regulators DICER1 and DGCR8 have recently been uncovered, revealing a potential novel mechanism driving thyroid tumor development. However, the true frequency of these hotspot mutations in follicular-patterned thyroid tumors (FTs) and their relation to established driver gene events remain elusive. METHODS: A total of 440 FTs from 2 institutions were interrogated for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38252873
DOI: 10.1210/clinem/dgae034
PMCID: PMC11180504

Genes

DICER1
DGCR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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