Article
Prevalence and Spectrum of DICER1 Mutations in Adult-onset Thyroid Nodules with Indeterminate Cytology.
The Journal of clinical endocrinology and metabolism - 25 Mar 2021
Chong Anne-Sophie, Nikiforov Yuri E, Condello Vincenzo, Wald Abigail I, Nikiforova Marina N, Foulkes William D, Rivera Barbara
Abstract excerpt
CONTEXT: DICER1 mutations are found in multinodular goiter and differentiated thyroid carcinoma in children, and can be a manifestation of DICER1 syndrome, but the prevalence of DICER1 mutations and their significance in adult-onset thyroid nodules is unknown. OBJECTIVE: Determine (1) the prevalence of DICER1 hotspot mutations in thyroid nodules; (2) the frequency of a second DICER1 pathogenic variant in thyroid...
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