Article
Genomic and transcriptomic analyses of thyroid cancers identify DICER1 somatic mutations in adult follicular-patterned RAS-like tumors.
Frontiers in endocrinology - 1 Jan 2023
Minna Emanuela, Devecchi Andrea, Pistore Federico, Paolini Biagio, Mauro Giuseppe, Penso Donata Alda, Pagliardini Sonia, Busico Adele, Pruneri Giancarlo, De Cecco Loris, Borrello Maria Grazia, Sensi Marialuisa, Greco Angela
Abstract excerpt
Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer (TC). Several genomic and transcriptomic studies explored the molecular landscape of follicular cell-derived TCs, and BRAFV600E, RAS mutations, and gene fusions are well-established drivers. DICER1 mutations were described in specific sets of TC patients but represent a rare event in adult TC patients. Methods: Here, we report...
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