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Article

DICER1 and DGCR8 in thyroid tumorigenesis: miRNA biogenesis and histopathologic diversity.

European thyroid journal - 1 Dec 2025

Rodrigues Lia, Sousa Martins Rui, Máximo Valdemar, Soares Paula, Vinagre Joao, Nosé Vania, Canberk Sule

Abstract excerpt

This review examines the emerging roles of DICER1 and DGCR8, key components of the miRNA biogenesis pathway, in thyroid pathogenesis, with a particular focus on their association with oncocytic morphology. Recent findings have expanded our understanding of DICER1 syndrome and DGCR8-related thyroid disorders, revealing a broader spectrum of thyroid lesions associated with mutations in these genes than previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41104964
DOI: 10.1530/ETJ-25-0188
PMCID: PMC12595409

Genes

DICER1
DGCR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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