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Article

DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer.

Frontiers in endocrinology - 1 Jan 2023

Ricarte-Filho Julio C, Casado-Medrano Victoria, Reichenberger Erin, Spangler Zachary, Scheerer Michele, Isaza Amber, Baran Julia, Patel Tasleema, MacFarland Suzanne P, Brodeur Garrett M, Stewart Douglas R, Baloch Zubair, Bauer Andrew J, Wasserman Jonathan D, Franco Aime T

Abstract excerpt

DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs. Somatic mutations in the RNase IIIb domain of DICER1 impair its ability to generate mature 5p miRNAs and are believed to drive tumorigenesis in DICER1 syndrome-associated and sporadic thyroid tumors. However, the DICER1-driven specific changes in miRNAs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36896180
DOI: 10.3389/fendo.2023.1083382
PMCID: PMC9990750

Genes

DICER1

Provenance

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