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Article

CD8+ chimeric antigen receptor T cells manufactured in absence of CD4+ cells exhibit hypofunctional phenotype.

Journal for immunotherapy of cancer - 20 Nov 2023

Lee Sang Yun, Lee Dong Hoon, Sun Wei, Cervantes-Contreras Francisco, Basom Ryan S, Wu Feinan, Liu Si, Rai Richa, Mirzaei Hamid R, O'Steen Shyril, Green Damian J, Shadman Mazyar, Till Brian G

Abstract excerpt

BACKGROUND: Cell culture conditions during manufacturing can impact the clinical efficacy of chimeric antigen receptor (CAR) T cell products. Production methods have not been standardized because the optimal approach remains unknown. Separate CD4+ and CD8+ cultures offer a potential advantage but complicate manufacturing and may affect cell expansion and function. In a phase 1/2 clinical trial, we observed poor...

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Identifiers

PMID: 38251688
DOI: 10.1136/jitc-2023-007803
PMCID: PMC10660840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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