Article
Transferrin-inspired iron delivery across the cell membrane using [(L 2 Fe) 2 (μ-O)] (L = chlorquinaldol) to harness anticancer activity of ferroptosis
1 Jan 2024
Abstract excerpt
(μ-O)] (1) that can mimic the function of the Fe(III)-transferrin complex in terms of the strong binding to Fe(III) and facile release of Fe(II) when the metal center is reduced. It should be noted that the cellular uptake of 1 is not transferrin receptor-mediated but enhanced by the high lipophilicity of chlorquinaldol. Once 1 is transported across the cell membrane, Fe(III) can be reduced by ferric reductase or...
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