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Article

H‐Chain Ferritin: A Natural Nuclei Targeting and Bioactive Delivery Nanovector

13 May 2015

Abstract excerpt

Nuclear translocation of human H-chain in its intact cage-like structure without any additional modifications enables a rapid nuclear delivery of an encapsulated anticancer drug (doxorubicin). This reduces the doses of drugs simultaneously bypassing the cellular multidrug resistance. Apoferritin exhibits synergistic effects through attenuating drug-induced dysregulation of the cellular iron. Tests on cerebellar...

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PMID: 25973730
DOI: 10.1002/adhm.201500226

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