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MOF-Based Nanoagent Enables NIR-Triggered Dual Damage to Mitochondria via Synergistically Reinforced Oxidative Stress and Calcium Overload

2021-04-15

Abstract excerpt

<title>Abstract</title> <p>We herein developed a core-shell type antitumor nanoagent based on the synergistically reinforced oxidative stress and calcium overload to mitochondria, both of which were triggered by near-infrared (NIR) light. The folic acid (FA) moiety decorated on MOF shells enabled efficient cellular uptake of nanoagents. The upconversion nanoparticle (UCNP) core converted NIR light to ultraviolet...

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Literature Corpus work
3409d0f2-9ebd-57f9-ab0c-075c9e42a23a
DOI
10.21203/rs.3.rs-379232/v1
Open publication

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MOF-Based Nanoagent Enables NIR-Triggered Dual Damage to Mitochondria via Synergistically Reinforced Oxidative Stress and Calcium OverloadDOI 10.21203/rs.3.rs-379232/v1
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