Article
The P286R mutation of DNA polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway.
Cell death & disease - 18 Jan 2024
Tang Ming, Yin Shasha, Zeng Hongliang, Huang Ao, Huang Yujia, Hu Zhiyi, Shah Ab Rauf, Zhang Shuyong, Li Haisen, Chen Guofang
Abstract excerpt
Endometrial carcinoma (EC) is a prevalent gynecological tumor in women, and its treatment and prevention are significant global health concerns. The mutations in DNA polymerase ε (POLE) are recognized as key features of EC and may confer survival benefits in endometrial cancer patients undergoing anti-PD-1/PD-L1 therapy. However, the anti-tumor mechanism of POLE mutations remains largely elusive. This study...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.