Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Clinical, Morphologic, and Molecular Comparison of Bonafide Spitz Melanomas and Atypical Spitz Tumors in the Pediatric Population

12 Mar 2025

Abstract excerpt

Pediatric Spitz melanoma (SM) with bonafide metastatic disease is rare. In this study, we assembled the largest cohort to date of pediatric SM with a verified Spitz-associated genomic driver and clinical follow-up demonstrating bonafide metastasis. We compared the clinical, morphologic, and molecular features of these SMs to a control cohort of 57 pediatric atypical Spitz tumors (ASTs). Pediatric SM patients were...

Topics

Join the communities discussing this publication.

Cancer Genomics and Diagnostics
Cutaneous Melanoma Detection and Management
Immunotherapy and Immune Responses

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40070296
DOI: 10.1097/pas.0000000000002381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Clinical, Morphologic, and Molecular Comparison of Bonafide Spitz Melanomas and Atypical Spitz Tumors in the Pediatric PopulationPMID 40070296Read ↗

Clinical, Morphologic, and Molecular Features of MAP3K8 Rearranged Spitz Neoplasms: A Retrospective Study Documenting That Bonafide Spitz Melanomas Are Rare.Semantic proximity Read ↗

Atypical Spitzoid Neoplasms in Childhood: A Molecular and Outcome StudySemantic proximity Read ↗

Outcomes of atypical spitz tumors with chromosomal copy number aberrations and conventional melanomas in children.Semantic proximity Read ↗

Clinical and pathologic findings of Spitz nevi and atypical Spitz tumors with ALK fusions.Semantic proximity Read ↗

Spitz melanoma is a distinct subset of spitzoid melanoma.Semantic proximity Read ↗

Toward a Molecular-Genetic Classification of Spitzoid Neoplasms.Semantic proximity Read ↗

A Clinicopathological Study of 29 Spitzoid Melanocytic Lesions With ALK Fusions, Including Novel Fusion Variants, Accompanied by Fluorescence In Situ Hybridization Analysis for Chromosomal Copy Number Changes, and Both TERT Promoter and Next-Generation Sequencing Mutation Analysis.Semantic proximity Read ↗

Activating Structural Alterations in MAPK Genes Are Distinct Genetic Drivers in a Unique Subgroup Of Spitzoid NeoplasmsSemantic proximity Read ↗

Kinase Fusions in Spitz Melanocytic Tumors: The Past, the Present, and the FutureSemantic proximity Read ↗

BRAF fusion Spitz neoplasms; clinical morphological, and genomic findings in six cases.Semantic proximity Read ↗

The Extended Spectrum of Morphologic and Molecular Findings in ALK Fusion Spitz Neoplasms : A Study of 144 Cases.Semantic proximity Read ↗

The Morpho-Molecular Landscape of Spitz Neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.