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A Clinical, Morphologic, and Molecular Comparison of Bonafide Spitz Melanomas and Atypical Spitz Tumors in the Pediatric Population.

The American journal of surgical pathology - 1 Jul 2025

Beydoun Haya Mary, Jeyakumar Julia Edwin, Addo Afua, Olivares Shantel, Zhao Lili, Ma Yangruijue, Ko Jennifer, Bahrami Armita, Florell Scott, Furtado Larissa V, Busam Klaus, Gerami Pedram

Abstract excerpt

Pediatric Spitz melanoma (SM) with bonafide metastatic disease is rare. In this study, we assembled the largest cohort to date of pediatric SM with a verified Spitz-associated genomic driver and clinical follow-up demonstrating bonafide metastasis. We compared the clinical, morphologic, and molecular features of these SMs to a control cohort of 57 pediatric atypical Spitz tumors (ASTs). Pediatric SM patients were...

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Identifiers

PMID: 40070296
DOI: 10.1097/PAS.0000000000002381

Genes

MYC
PTEN
TERT

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