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Article

Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2012

Khalili Jahan S, Yu Xiaoxing, Wang Ji, Hayes Brendan C, Davies Michael A, Lizee Gregory, Esmaeli Bita, Woodman Scott E

Abstract excerpt

PURPOSE: Activating Q209L/P mutations in GNAQ or GNA11 (GNAQ/11) are present in approximately 80% of uveal melanomas. Mutant GNAQ/11 are not currently therapeutically targetable. Inhibiting key down-stream effectors of GNAQ/11 represents a rational therapeutic approach for uveal melanomas that harbor these mutations. The mitogen-activated protein/extracellular signal-regulated kinase/mitogen-activated protein...

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Source

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Identifiers

PMID: 22733540
DOI: 10.1158/1078-0432.CCR-11-3227
PMCID: PMC3935730

Genes

GNAQ
GNA11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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