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Article

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

27 Oct 2011

Abstract excerpt

In sexual reproduction of most animals, the spermatozoon provides DNA and centrioles, together with some cytoplasm and organelles, to the oocyte that is being fertilized. Paternal mitochondria and their genomes are generally eliminated in the embryo by an unknown degradation mechanism. We show that, upon fertilization, a Caenorhabditis elegans spermatozoon triggers the recruitment of autophagosomes within minutes...

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PMID: 22033522
DOI: 10.1126/science.1211878

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