Getting a handle on hereditary CEBPA mutations

Abstract excerpt

In this issue of Blood , Tawana et al describe 24 patients with acute myeloid leukemia (AML) within 10 families with germline, ie, hereditary, mutations in the CCAAT/enhancer binding protein α ( CEBPA ) gene. Distinct biology and clinical outcomes, including unique patterns of “relapse,” are identified. 1

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