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Article

First FHM3 mouse model shows spontaneous cortical spreading depolarizations

27 Dec 2019

Abstract excerpt

Abstract Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α 1 subunits in voltage‐gated Na V 1.1 sodium channels ( Scn1a L263V ). CSDs consistently propagated from...

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PMID: 31880072
DOI: 10.1002/acn3.50971

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