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Article

High overall copy number variation burden by genome-wide methylation profiling holds negative prognostic value in surgically treated pancreatic ductal adenocarcinoma.

Human pathology - 1 Dec 2023

Detlefsen Sönke, Boldt Henning Bünsow, Burton Mark, Thomsen Mikkel Marschall, Rasmussen Lukas Gammelgaard, Ørbeck Siri Vreim, Pfeiffer Per, Mortensen Michael Bau, de Stricker Karin

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive type of cancer with an overall 5-year survival of around 10 %. New prognostic tools to stratify patients are needed. Our main aim was to evaluate the prognostic value of overall copy number variation (CNV) burden in surgically treated PDAC. DNA extracted from 108 surgical PDAC specimens was examined to collect data on the genome-wide DNA methylation status...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37977512
DOI: 10.1016/j.humpath.2023.11.002

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