Characterization of pancreatic ductal adenocarcinoma using whole transcriptome sequencing and copy number analysis by single-nucleotide polymorphism array.

doi:10.3892/mmr.2015.4344

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Article

Characterization of pancreatic ductal adenocarcinoma using whole transcriptome sequencing and copy number analysis by single-nucleotide polymorphism array.

Molecular medicine reports - 1 Nov 2015

Di Marco Mariacristina, Astolfi Annalisa, Grassi Elisa, Vecchiarelli Silvia, Macchini Marina, Indio Valentina, Casadei Riccardo, Ricci Claudio, D'Ambra Marielda, Taffurelli Giovanni, Serra Carla, Ercolani Giorgio, Santini Donatella, D'Errico Antonia, Pinna Antonio Daniele, Minni Francesco, Durante Sandra, Martella Laura Raffaella, Biasco Guido

Abstract excerpt

The aim of the current study was to implement whole transcriptome massively parallel sequencing (RNASeq) and copy number analysis to investigate the molecular biology of pancreatic ductal adenocarcinoma (PDAC). Samples from 16 patients with PDAC were collected by ultrasound‑guided biopsy or from surgical specimens for DNA and RNA extraction. All samples were analyzed by RNASeq performed at 75x2 base pairs on a...

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PMID: 26397140
DOI: 10.3892/mmr.2015.4344

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SMAD4

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