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Article

Assessment of the biochemical basis underlying the resistance against systemic amyloidosis.

Scientific reports - 9 Jan 2026

Moderer Tim, Schnell Adrian F, Scheurmann Natalie J, Schmidt Matthias, Haupt Christian, Schwierz Nadine, Fändrich Marcus

Abstract excerpt

Amyloid resistance is the reduced or abrogated ability of an organism to develop a specific type of amyloid disease. For example, it was found that certain mouse strains show resistance against systemic AA amyloidosis, due to mutations in the amyloid fibril precursor protein serum amyloid A (SAA). In this research, we find that the SAA1.5 and 2.2, two SAA-isoforms that underlie amyloid resistance in mice are...

Topics

Animals
Serum Amyloid A Protein
Amyloidosis
Amyloid
Mice
Molecular Dynamics Simulation
Protein Isoforms
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41513812
DOI: 10.1038/s41598-026-35297-9
PMCID: PMC12796397

Genes

SAA1
SAA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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