Article

Evolutionary and Structural Constraints Influencing Apolipoprotein A-I Amyloid Behaviour

2020-09-20

Abstract excerpt

Apolipoprotein A-I (apoA-I) has a key function in the reverse cholesterol transport mediated by the high density lipoprotein (HDL) particles. However, aggregation of apoA-I single point mutants can lead to hereditary amyloid pathology. Although several studies have tackled the biophysical and structural impacts introduced by these mutations, there is little information addressing the relationship between the evolu...

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Literature Corpus work: 440bdf95-e7a6-592c-b392-9b341a367c45
DOI: 10.1101/2020.09.18.304337

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