Article
Dissenting degradation: Deubiquitinases in cell cycle and cancer.
Seminars in cancer biology - 1 Dec 2020
Bonacci Thomas, Emanuele Michael J
Abstract excerpt
Since its discovery forty years ago, protein ubiquitination has been an ever-expanding field. Virtually all biological processes are controlled by the post-translational conjugation of ubiquitin onto target proteins. In addition, since ubiquitin controls substrate degradation through the action of hundreds of enzymes, many of which represent attractive therapeutic candidates, harnessing the ubiquitin system to...
Topics
- Cell Cycle
- Deubiquitinating Enzyme CYLD
- Deubiquitinating Enzymes
- Gene Expression Regulation, Neoplastic
- Humans
- Mitosis
- Mutation
- Neoplasms
- Tumor Suppressor Proteins
- Ubiquitin Thiolesterase
- Ubiquitin-Specific Peptidase 7